Chronic subthreshold cortical stimulation and stimulation-related EEG biomarkers for focal epilepsy

Chronic Subthreshold Cortical Stimulation to Treat Focal Epilepsy.

Deep brain and cortical stimulation for epilepsy.

BACKGROUND Despite optimal medical treatment, including epilepsy surgery, many epilepsy patients have uncontrolled seizures. In the last decades, interest has grown in invasive intracranial neurostimulation as a treatment for these patients. Intracranial stimulation includes both deep brain stimulation (DBS) (stimulation through depth electrodes) and cortical stimulation (subdural electrodes). ...

TMS: A Tailored Method of Stimulation for Refractory Focal Epilepsy?

Commentary Neurostimulation-based treatments for epilepsy are an alternative for the many patients who remain refractory to standard antiepileptic drugs (AEDs), but modalities such as vagus nerve stimulation, deep brain stimulation, and responsive neurostimulation require surgical implanta-tion of hardware and are accompanied by attendant risks (1). Transcranial magnetic stimulation (TMS), by c...

Occipital nerve stimulation for chronic migraine: a randomized trial on subthreshold stimulation.

INTRODUCTION Occipital nerve stimulation (ONS) may provide pain relief in migraine patients. In this double-blinded trial we investigated the significance of paresthesia and possible placebo effects. METHODS Patients already treated with ONS reporting stable treatment effect were included. "Effective stimulation," "subthreshold stimulation" and "no stimulation" were compared. Patients cycled ...

Brain Stimulation for Epilepsy

Ignited by the efficacy and commercial success of cardiac devices, neurologists, neurosurgeons, and biomedical engineers are collaborating to develop implantable brain devices to arrest, contain, and preempt seizures before they cause clinical symptoms. New devices in development deliver electrical stimulation or pharmacologic agents locally to the epileptic focus or deep nuclei to modulate sei...